Preterm Prevention Clinic

Samitivej Sukhumvit Hospital

KEY services & Treatments

Services Genetic Screening/Testing (Precise and Personalized Medicine)

  • Check for genetic disease carriers in couples considering having a baby
  • Check for genetic causes of infertility
    • Genetic Testing of Infertile Couples
      • Pre-pregnancy genetic screening: with the autosomal recessive and X-linked screening, the at-risk couple detection rate is 3.4%.
      • Pre-implantation diagnosis or PGD (NGS): embryos are screened for recessive genetic conditions before implantation, so that future children are free of genetic problems with an accuracy rate of 95%.
      • Pre-implantation screening or PGS (NGS): screening embryos for chromosomal abnormalities can increase pregnancy rates (from 30% to 55%) and detect the chromosomal abnormalities present in more than 50% of embryos.
      • Embryo selection: using Mitochondrial DNA content as a viability score in embryos can increase the implantation rate from 0% to 59-81%.
      • Endometrium receptivity analysis (238 gene expression): 25% of women were found to have a non-receptive uterine lining at a time it was expected to be receptive, causing a pregnancy rate reduction by half and leading to a 100% chance of miscarriage.
      • Gene testing in infertility (in process): finding the cause of infertility through genetic testing.

Immunological infertility issues causing implantation failure and recurrent miscarriage:

  • Autoimmune antibodies: anti-thyroid peroxidase, ANA, anti-mitochondria antibodies (in process)
  • Thrombophilia screening
  • Immune tests:
    • Natural killer cell assay and immune-phenotype
    • Th1 (T helper 1) / Th2 (T helper 2) intracellular cytokine ratios (Successful pregnancy rate 39%)
  • Check for genetic diseases in the unborn fetus
    • Pre-pregnancy or early pregnancy genetic screening: autosomal recessive and X-linked screening
    • Non-invasive prenatal testing: testing of cell-free fetal DNA in the maternal plasma for Down’s syndrome
    • Prenatal Diagnosis (PND): Chorionic Villus Sampling (CVS), Amniocentesis, Cordocentesis
    • Karyotyping / Chromosomal Microarray Analysis (CMA) / Next Generation Sequencing (NGS)
    • Genetic Diagnosis in Fetus: whole exome sequencing, whole genome sequencing (research)
  • Check the immune system of those with infertility and who experience failed embryo transfers and repeated miscarriages